The involvement of serotonin in the mechanism of central action of apomorphine

Abstract

The paper reviews and summarizes the results obtained in a series of experimental papers on the action of apomorphine on central serotonin mechanisms. Apomorphine accelerates utilization of serotonin in the central nervous system, this effect being a consequence of stimulation of central dopamine receptors. The activation of serotonergic mechanisms may be responsible for the hypothermizing action of apomorphine in rats and mice, pi modulates the locomotor stimulation produced by apomorphine in the rat, and does not influence the apomorphine-induced stereotypy in the rat.