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Case Reports
. 1994 Jan 8;343(8889):85-6.
doi: 10.1016/s0140-6736(94)90817-6.

Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes

R L Smyth  1 , D van Velzen, A R Smyth, D A Lloyd, D P Heaf
Affiliations
Case Reports

Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes

R L Smyth et al. Lancet. .

Abstract

We have observed five children with cystic fibrosis, who presented over 2 months, with meconium ileus equivalent that failed to respond to medical management. At surgery, four had a stricture in the ascending colon, and all had histopathological changes of post-ischaemic ulceration repair, with mucosal and submucosal fibrosis. The only common change in the management of these children was a switch from conventional enteric-coated pancreatic enzymes to high-strength products 12-15 months before presentation.

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