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. 1993 Sep-Oct;78(5):261-3.

The expression of the multidrug resistance related glycoprotein in adult acute lymphoblastic leukemia

C Savignano  1 , A Geromin, M Michieli, D Damiani, A Michelutti, C Melli, R Fanin, M Baccarani
Affiliations
  • PMID: 7906239

The expression of the multidrug resistance related glycoprotein in adult acute lymphoblastic leukemia

C Savignano et al. Haematologica. 1993 Sep-Oct.

Abstract

Background: More than 50% of adults with acute lymphoblastic leukemia (ALL) actually die with resistant leukemia. The multidrug resistance (MDR) related P170 glycoprotein may be involved in treatment failure.

Methods: P170 content of leukemic cells was assayed by immunocytochemistry with the MRK-16 monoclonal antibody in 41 consecutive cases of adult ALL (27 at onset and 14 at relapse).

Results: Positive cells were found in 11/14 cases at relapse and in 18/27 cases at onset. All cases with a high WBC, FAB L3, B-mature phenotype, and t(9; 22) were positive. In the 27 patients who were studied at onset and were treated with the same protocol, the overall failure rate was 44% in negative cases and 83% in positive cases.

Conclusion: P170 overexpression may contribute to drug resistance and to chemotherapy failure in adult ALL.

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