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. 1994 Mar 5;343(8897):577-8.
doi: 10.1016/s0140-6736(94)91524-5.

Disseminated active HHV-6 infections in patients with AIDS

K K Knox  1 , D R Carrigan
Affiliations

Disseminated active HHV-6 infections in patients with AIDS

K K Knox et al. Lancet. .

Abstract

Human herpesvirus 6 (HHV-6) infected cells were detected in all lung, lymph-node, spleen, liver, and kidney tissues obtained at necropsy from an unselected series of nine patients with AIDS. This infection rate was significantly higher than that for cytomegalovirus. Lung infection with HHV-6 was extensive enough in one patient to account for fatal pneumonitis. In other tissues increased numbers of HHV-6 infected cells were related to the presence of lymphocytes infiltrates or residual lymphoid tissue, with lymphocytes being predominantly infected. Thus HHV-6 is an important pathogen in patients with AIDS.

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Comment in

  • Human herpesvirus 6 in AIDS.
    Lusso P, Gallo RC. Lusso P, et al. Lancet. 1994 Mar 5;343(8897):555-6. doi: 10.1016/s0140-6736(94)91515-6. Lancet. 1994. PMID: 7906323 No abstract available.
  • HHV-6 in AIDS.
    Griffiths PD, Emery VC, Lee C, Johnson MA, McLaughlin J. Griffiths PD, et al. Lancet. 1994 Apr 30;343(8905):1104-5. doi: 10.1016/s0140-6736(94)90218-6. Lancet. 1994. PMID: 7909128 No abstract available.
  • HHV-6 and CMV pneumonitis in immunocompromised patients.
    Lusso P, Gallo RC. Lusso P, et al. Lancet. 1994 Jun 25;343(8913):1647-8. Lancet. 1994. PMID: 7911958 No abstract available.

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