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. 1994 Mar 19;343(8899):704-6.
doi: 10.1016/s0140-6736(94)91582-2.

Peptide therapy for diabetes in NOD mice

D Elias  1 , I R Cohen
Affiliations

Peptide therapy for diabetes in NOD mice

D Elias et al. Lancet. .

Abstract

NOD mice spontaneously develop autoimmune diabetes that mimics insulin-dependent diabetes mellitus (IDDM) in man. A peptide of the 60 kDa heat shock protein (hsp60), designated p277, can serve as a target for diabetogenic T-cell clones, and diabetes was prevented by using the p277 peptide to turn off anti-p277 immunity early in life. We report that the p277 peptide, administered once, can arrest the autoimmune process even after it is far advanced. Successful therapy was associated with down-regulation of the autoimmune process and regression of islet inflammation. Thus the immune system is responsive to manipulation by a specific signal even in the face of a virulent, full-blown autoimmune process.

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Comment in

  • IDDM: long honeymoon, sweet ending.
    Williams G. Williams G. Lancet. 1994 Mar 19;343(8899):684-5. doi: 10.1016/s0140-6736(94)91574-1. Lancet. 1994. PMID: 7907674 No abstract available.
  • Peptide therapy for diabetes.
    Jones DB, Armstrong NW. Jones DB, et al. Lancet. 1994 May 7;343(8906):1168-9. doi: 10.1016/s0140-6736(94)90278-x. Lancet. 1994. PMID: 7910263 No abstract available.

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