Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Mar;95(3):450-4.
doi: 10.1111/j.1365-2249.1994.tb07017.x.

HIV-1 infection of monocyte-derived macrophages reduces Fc and complement receptor expression

S J Kent  1 , G Stent, S Sonza, S D Hunter, S M Crowe
Affiliations

HIV-1 infection of monocyte-derived macrophages reduces Fc and complement receptor expression

S J Kent et al. Clin Exp Immunol. 1994 Mar.

Abstract

Fc receptor (FcR) and complement receptor (CR) expression on HIV-infected monocyte-derived macrophages may be an important determinant of immune function. We studied the effects of HIV-1 infection of macrophages in vitro on FcR and CR expression. Macrophages were infected with HIV-1DV 7 days following isolation, and the expression of Fc gamma RI-III and CR3 were measured at intervals thereafter by flow cytometry. We found a reduction in receptor expression with the percentage of cells expressing FcRI 14 days post infection declining from 77% to 13%, FcRII fell from 96% to 85%, FcRIII from 45% to 9%, and CR3 from 91% to 67% 14 days following infection. As these receptors are important for macrophage function, their down-modulation may contribute to the pathogenesis of HIV-related disease.

PubMed Disclaimer

References

    1. Scand J Immunol. 1987 Oct;26(4):371-9 - PubMed
    1. AIDS Res Hum Retroviruses. 1988 Apr;4(2):121-9 - PubMed
    1. J Infect Dis. 1988 Aug;158(2):483-6 - PubMed
    1. Rev Infect Dis. 1988 Nov-Dec;10(6):1142-54 - PubMed
    1. J Cell Sci Suppl. 1988;9:45-65 - PubMed

Publication types

MeSH terms