doi: 10.1016/0006-8993(94)90186-4.
Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study
Affiliations
- PMID: 7908850
- DOI: 10.1016/0006-8993(94)90186-4
Item in Clipboard
Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study
Brain Res.
.
Abstract
Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.
Similar articles
-
Naloxone-precipitated morphine withdrawal increases pontine glutamate levels in the rat.Life Sci. 1994;55(2):PL25-31. doi: 10.1016/0024-3205(94)90108-2. Life Sci. 1994. PMID: 7912397
-
Precipitated kappa-opioid receptor agonist withdrawal increase glutamate in rat locus coeruleus.Eur J Pharmacol. 1996 Oct 31;314(3):301-6. doi: 10.1016/s0014-2999(96)00569-9. Eur J Pharmacol. 1996. PMID: 8957250
-
Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens of chronically morphine-treated rats: an in vivo microdialysis study.Pharmacol Biochem Behav. 1998 May;60(1):255-62. doi: 10.1016/s0091-3057(97)00550-9. Pharmacol Biochem Behav. 1998. PMID: 9610950
-
The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal.Neuropsychopharmacology. 1995 Dec;13(4):295-300. doi: 10.1016/0893-133X(95)00082-O. Neuropsychopharmacology. 1995. PMID: 8747753 Review.
-
Afferent effects on locus coeruleus in opiate withdrawal.Prog Brain Res. 1991;88:207-16. doi: 10.1016/s0079-6123(08)63810-8. Prog Brain Res. 1991. PMID: 1839935 Review.
Cited by
-
Caudate nucleus volume mediates the link between glutamatergic neurotransmission and problematic smartphone use in youth.J Behav Addict. 2021 Apr 26;10(2):338-346. doi: 10.1556/2006.2021.00024. Print 2021 Jul 15. J Behav Addict. 2021. PMID: 33905351 Free PMC article.
-
Interactions of nitric oxide with α2 -adrenoceptors within the locus coeruleus underlie the facilitation of inhibitory avoidance memory by agmatine.Br J Pharmacol. 2016 Sep;173(17):2589-99. doi: 10.1111/bph.13531. Epub 2016 Aug 1. Br J Pharmacol. 2016. PMID: 27273730 Free PMC article.
-
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.Naunyn Schmiedebergs Arch Pharmacol. 2003 Aug;368(2):113-8. doi: 10.1007/s00210-003-0773-9. Epub 2003 Jul 17. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12879207
-
The effect of vitamin C on morphine self-administration in rats.Adv Biomed Res. 2014 Aug 26;3:178. doi: 10.4103/2277-9175.139524. eCollection 2014. Adv Biomed Res. 2014. PMID: 25250292 Free PMC article.
-
Effects of novel beta-lactam, MC-100093, and ceftriaxone on astrocytic glutamate transporters and neuroinflammatory factors in nucleus accumbens of C57BL/6 mice exposed to escalated doses of morphine.Saudi Pharm J. 2024 Jul;32(7):102108. doi: 10.1016/j.jsps.2024.102108. Epub 2024 May 23. Saudi Pharm J. 2024. PMID: 38868175 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
