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Review
. 1994 Jun 9;330(23):1663-70.
doi: 10.1056/NEJM199406093302307.

The pharmacology and use of H1-receptor-antagonist drugs

F E Simons  1 , K J Simons
Affiliations
Review

The pharmacology and use of H1-receptor-antagonist drugs

F E Simons et al. N Engl J Med. .

Abstract

The second-generation H1-antagonist drugs are supplanting their predecessors in the treatment of allergic rhinoconjunctivitis and chronic urticaria. Their use can be justified mainly on the basis of a more favorable risk-benefit ratio, because they are less toxic to the central nervous system. Future research into H1 antagonists should include additional dose-response studies in patients with allergic disorders, especially children and the elderly; objective studies of adverse effects; studies of topical mucosal application of H1 antagonists; and studies of H1-antagonist enantiomers and active metabolites. With the cloning of the gene encoding the H1 receptor and increased understanding of the precise structural requirements for H1-receptor activity, H1 antagonists with an even more favorable therapeutic index may be developed.

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Comment in

  • Histamine H1 antagonists.
    Fleischer AB Jr. Fleischer AB Jr. N Engl J Med. 1994 Oct 13;331(15):1019; author reply 1020. doi: 10.1056/NEJM199410133311512. N Engl J Med. 1994. PMID: 7916123 No abstract available.
  • Histamine H1 antagonists.
    Walls RM. Walls RM. N Engl J Med. 1994 Oct 13;331(15):1019; author reply 1020. N Engl J Med. 1994. PMID: 7916124 No abstract available.
  • Histamine H1 antagonists.
    Weintraub M. Weintraub M. N Engl J Med. 1994 Oct 13;331(15):1019; author reply 1020. N Engl J Med. 1994. PMID: 7916125 No abstract available.
  • Histamine H1 antagonists.
    Barr DA. Barr DA. N Engl J Med. 1994 Oct 13;331(15):1020. doi: 10.1056/NEJM199410133311513. N Engl J Med. 1994. PMID: 7916126 No abstract available.

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