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Clinical Trial
. 1976 Sep 17;222(1):69-75.
doi: 10.1007/BF00369796.

[Deanol in tardive dyskinesia: a double-blind study (author's transl)]

[Article in German]
S Bockenheimer, G Lucius
Clinical Trial

[Deanol in tardive dyskinesia: a double-blind study (author's transl)]

[Article in German]
S Bockenheimer et al. Arch Psychiatr Nervenkr (1970). .

Abstract

Tardive dyskinesia following long-term application of neuroleptics is resistant to treatment. According to the hypothesis of a relative central nervous system acetylcholine lack as the underlying mechanism 20 patients were treated with dimethylaminoethanol (Deanol) in a double-blind study. Deanol is known to be a direct precursor of intracerebral acetylcholine. For several reasons (which are discussed) the data of but 11 patients were statistically evaluated. The results suggest some therapeutic effect in some of the patients only (significant improvement of oral hyperkinesia).

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