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Clinical Trial
. 1976 Nov 20;2(6046):1229-31.
doi: 10.1136/bmj.2.6046.1229.

Reduced respiratory responses to carbon dioxide after propranolol: a central action

C P Mustchin, H R Gribbin, A E Tattersfield, C F George
Clinical Trial

Reduced respiratory responses to carbon dioxide after propranolol: a central action

C P Mustchin et al. Br Med J. .

Abstract

In a double-blind study in six subjects propranolol significantly reduced the respiratory sensitivity to carbon dioxide rebreathing. This effect seems to have been due to beta-adrenergic blockade, since it was not seen with D-propranolol. In two subjects increasing doses of propranolol caused progressive reductions in respiratory sensitivity to values below normal and similar to those of patients with ventilatory failure. These changes are probably due to a central action of propranolol.

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References

    1. Lancet. 1964 Nov 21;2(7369):1101-2 - PubMed
    1. Am J Cardiol. 1966 Sep;18(3):473-5 - PubMed
    1. Br J Pharmacol Chemother. 1953 Mar;8(1):98-102 - PubMed
    1. Br J Pharmacol. 1974 May;51(1):148P - PubMed
    1. Br Med J. 1969 Jul 19;3(5663):143-5 - PubMed

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