Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Aug 27;344(8922):583-4.
doi: 10.1016/s0140-6736(94)91968-2.

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer

H E Mulcahy  1 , M J Duffy, D Gibbons, P McCarthy, N A Parfrey, D P O'Donoghue, K Sheahan
Affiliations

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer

H E Mulcahy et al. Lancet. .

Abstract

Urokinase-type plasminogen activator (u-PA) is a serine protease involved in cancer metastasis. Using immunohistochemical methods, we examined the relation between u-PA and long-term survival in 70 patients with Dukes' B colorectal cancer. 8-year survival was 81% in patients whose tumours demonstrated low-grade epithelial u-PA staining and 43% in those with high-grade staining (log-rank test, p = 0.01). Survival was unrelated to stromal u-PA staining. These results suggest that u-PA may be useful in the identification of patients with non-metastatic colorectal cancer at risk of tumour recurrence.

PubMed Disclaimer

Substances