[The detection of antibodies to the hantaan virus in the urine of patients with hemorrhagic fever with renal syndrome]

Abstract

Using a commercial diagnostic preparation for indirect IFA test, 135 urine samples from 50 patients with HFRS were examined at different periods of the disease. Antibodies were demonstrable in all urine specimens from HFRS patients for 13 days. In 14-20 days they could be detected in half of the patients, and no antibodies could be demonstrated since the 21st day on. The results of urine examination from healthy subjects and some patients with other clinical diagnoses were negative same as controls with normal antigen. The dynamics of antibody titres in the patients' urine differed from that in the blood and was considered as "decreasing" similarly as the clinical disease. The antibody excretion in the urine coincided with the period of renal structure damage and stopped when the normal renal function was restored. The data are discussed from the point of view of the pathogenesis and diagnosis. Special attention was paid to the possibility and advantages of early HFRS diagnosis by antibody determinations in the patients' urine.