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Meta-Analysis
. 1994 May;24(2):307-16.
doi: 10.1017/s003329170002729x.

Antipsychotic drugs: is more worse? A meta-analysis of the published randomized control trials

P Bollini  1 , S Pampallona, M J Orza, M E Adams, T C Chalmers
Affiliations
Meta-Analysis

Antipsychotic drugs: is more worse? A meta-analysis of the published randomized control trials

P Bollini et al. Psychol Med. 1994 May.

Abstract

Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.

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