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. 1993 Feb 20;1172(1-2):190-2.
doi: 10.1016/0167-4781(93)90292-l.

Structure of the human apolipoprotein D gene promoter region

J Lambert  1 , P R Provost, Y L Marcel, E Rassart
Affiliations

Structure of the human apolipoprotein D gene promoter region

J Lambert et al. Biochim Biophys Acta. .

Abstract

A human genomic clone of 18.2 kbp encompassing the apolipoprotein D (apoD) exon-1 and 2 and 10 kbp of upstream sequence was isolated and characterized. DNA sequencing and primer extension analysis revealed a transcriptional initiation site located 27 bp downstream of a consensus TATA box sequence. The exon 1 was 66 bp long. Computer analysis of DNA sequence from positions -557 to +129 revealed some putative transcriptional regulatory elements including a stretch of (pyrimidine/purine)26 located from nucleotide -263 to nucleotide -212, which could potentially form Z-DNA. Steroid hormone regulatory elements were identified which may be related to the modulation of apoD gene expression by androgens and estrogens in vitro.

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