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. 1993 Aug;77(1):43-52.
doi: 10.1006/expr.1993.1059.

Leishmania major: characterisation and expression of a cytoplasmic stress-related protein

S Searle  1 , D F Smith
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Leishmania major: characterisation and expression of a cytoplasmic stress-related protein

S Searle et al. Exp Parasitol. 1993 Aug.

Abstract

The DNA sequence of a single-copy gene from Leishmania major has been determined and shown to share sequence identity with eukaryotic heat shock protein-70-related genes. Conserved features of the deduced open reading frame include amino acids implicated in ATP binding and a putative calmodulin-binding domain. Antibodies generated to the recombinant fusion protein recognise a 70-kDa molecule of pI 6.0. This molecule is constitutively expressed and localises to the cytoplasm in all stages of the parasite life cycle.

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