Review
doi: 10.1016/0167-5699(94)90173-2.
The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases
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- PMID: 7916948
- DOI: 10.1016/0167-5699(94)90173-2
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Review
The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases
Immunol Today.
1994 Aug.
Abstract
A variety of experimental approaches are currently being evaluated for controlling CD4+ T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases.
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