Macromolecular crowding and molecular recognition
- PMID: 7917416
- DOI: 10.1002/jmr.300060410
Macromolecular crowding and molecular recognition
Abstract
The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, are reviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.
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