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Comparative Study
. 1994 Oct 12;1195(1):181-4.
doi: 10.1016/0005-2736(94)90025-6.

Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo

V P Torchilin  1 , M I Shtilman, V S Trubetskoy, K Whiteman, A M Milstein
Affiliations
Comparative Study

Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo

V P Torchilin et al. Biochim Biophys Acta. .

Abstract

Newly synthesized amphiphilic polyacrylamide and poly(vinyl pyrrolidone), single terminus-modified with long-chain fatty acyl groups, are able to incorporate into the liposomal membrane, and similar to poly(ethylene glycol) prolong liposome circulation in vivo and decrease liposome accumulation in the liver. Protective efficacy of modified polymers increases with the increase in the length of acyl moiety and decreases for higher molecular weight polymers. The data on amphiphilic polymer-modified liposome biodistribution are presented.

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