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Review
. 1994 Apr;12(4):433-62.
doi: 10.1016/0731-7085(94)80027-8.

Chemiluminescence and immunoassays

H A Rongen  1 , R M Hoetelmans, A Bult, W P van Bennekom
Affiliations
Review

Chemiluminescence and immunoassays

H A Rongen et al. J Pharm Biomed Anal. 1994 Apr.

Abstract

The principles of chemiluminescence and the application of chemiluminescent labels and substrates in immunoassays are reviewed. Various immunoassay formats and all known classes of chemiluminescent molecules, including 1,2-dioxetanes, luminol and derivatives, acridinium esters, oxalate esters and firefly luciferins are described as well as the many sensitizers and fluorescent enhancers. Recent promising developments are discussed.

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