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. 1994 Jun;7(2):125-9.
doi: 10.1038/ng0694-125.

Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor

T Shirakawa  1 , A Li, M Dubowitz, J W Dekker, A E Shaw, J A Faux, C Ra, W O Cookson, J M Hopkin
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Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor

T Shirakawa et al. Nat Genet. 1994 Jun.

Abstract

The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.

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Comment in

  • Atopy in Australia.
    Duffy DL, Healey SC, Chenevix-Trench G, Martin NG, Weger J, Lichter J. Duffy DL, et al. Nat Genet. 1995 Jul;10(3):260. doi: 10.1038/ng0795-260a. Nat Genet. 1995. PMID: 7670462 No abstract available.

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