Review
doi: 10.1016/s0960-9822(00)00127-5.
Combinatorial libraries. Finding the needle in the haystack
Affiliations
- PMID: 7922382
- DOI: 10.1016/s0960-9822(00)00127-5
Item in Clipboard
Review
Combinatorial libraries. Finding the needle in the haystack
Curr Biol.
.
Abstract
Combinatorial libraries are at the forefront of a revolution in basic research and drug discovery. They allow highly active compounds to be selected from hundreds of millions of others on the basis of biological activity.
Similar articles
-
Focus-2D: a new approach to the design of targeted combinatorial chemical libraries.Pac Symp Biocomput. 1998:305-16. Pac Symp Biocomput. 1998. PMID: 9697191
-
Generation and utilization of synthetic combinatorial libraries.Mol Med Today. 1995 Jul;1(4):174-80. doi: 10.1016/s1357-4310(95)91867-1. Mol Med Today. 1995. PMID: 9415154 Review.
-
Solid-phase combinatorial chemistry and novel tagging methods for identifying leads.Curr Opin Biotechnol. 1995 Dec;6(6):632-9. doi: 10.1016/0958-1669(95)80104-9. Curr Opin Biotechnol. 1995. PMID: 8527833 Review.
-
Combinatorial chemistry in the discovery and development of drugs.J Chem Technol Biotechnol. 1995 Dec;64(4):317-24. doi: 10.1002/jctb.280640402. J Chem Technol Biotechnol. 1995. PMID: 8579821 Review. No abstract available.
-
Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.J Med Chem. 1994 Apr 29;37(9):1233-51. doi: 10.1021/jm00035a001. J Med Chem. 1994. PMID: 8176700 Review. No abstract available.
Cited by
-
A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.ACS Chem Biol. 2019 Jun 21;14(6):1183-1194. doi: 10.1021/acschembio.9b00093. Epub 2019 May 13. ACS Chem Biol. 2019. PMID: 31058487 Free PMC article.
-
Insights into the evolution of lanthipeptide biosynthesis.Protein Sci. 2013 Nov;22(11):1478-89. doi: 10.1002/pro.2358. Epub 2013 Sep 18. Protein Sci. 2013. PMID: 24038659 Free PMC article. Review.
-
Marine natural products: a new wave of drugs?Future Med Chem. 2011 Sep;3(12):1475-89. doi: 10.4155/fmc.11.118. Future Med Chem. 2011. PMID: 21882941 Free PMC article.
-
Xanthines as a scaffold for molecular diversity.Mol Divers. 1997;2(3):171-4. doi: 10.1007/BF01682205. Mol Divers. 1997. PMID: 9238648
-
Combinatorial thinking in chemistry and biology.Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2779-82. doi: 10.1073/pnas.94.7.2779. Proc Natl Acad Sci U S A. 1997. PMID: 9096292 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
