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. 1994 Aug;47(8):862-9.
doi: 10.7164/antibiotics.47.862.

Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. I. Taxonomy of the producing organism, fermentation and biological activity

J P Karwowski  1 , M Jackson, G Sunga, P Sheldon, J B Poddig, W L Kohl, S Kadam
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Free article

Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. I. Taxonomy of the producing organism, fermentation and biological activity

J P Karwowski et al. J Antibiot (Tokyo). 1994 Aug.
Free article

Abstract

The dorrigocins are new secondary metabolites produced by submerged fermentation of a streptomycete which was isolated from a soil sample collected in Australia. The dorrigocins show moderate antifungal activity and reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The producing culture was identified as Streptomyces platensis subsp. rosaceus strain AB1981F-75.

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