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. 1994 Jun;33(6):1127-35.
doi: 10.1093/jac/33.6.1127.

Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum

K Yazawa  1 , Y Mikami, A Maeda, N Morisaki, S Iwasaki
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Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum

K Yazawa et al. J Antimicrob Chemother. 1994 Jun.

Abstract

Rifampicin was inactivated by Nocardia otitidiscaviarum to yield two products designated RIP-3 and RIP-4. The full structures of RIP-3 and RIP-4 were determined to be 21-(O-phosphoryl) rifampicin and 3-formyl-21-(O-phosphoryl) rifamycin SV, respectively, but neither product had any antimicrobial activity.

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