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. 1994 Oct 20;371(6499):674-80.
doi: 10.1038/371674a0.

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

B Ensoli  1 , R Gendelman, P Markham, V Fiorelli, S Colombini, M Raffeld, A Cafaro, H K Chang, J N Brady, R C Gallo
Affiliations

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

B Ensoli et al. Nature. .

Abstract

Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.

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