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Clinical Trial
. 1994 Sep;44(9):1701-5.
doi: 10.1212/wnl.44.9.1701.

The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study

R C Smits  1 , H H Emmen, F W Bertelsmann, B M Kulig, A C van Loenen, C H Polman
Affiliations
Clinical Trial

The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study

R C Smits et al. Neurology. 1994 Sep.

Abstract

4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.

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