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Clinical Trial
. 1994 Jun;42(6):299-304.

[The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]

[Article in Italian]
M R Cesarone  1 , G Laurora, M T De Sanctis, L Incandela, R Grimaldi, C Marelli, G Belcaro
Affiliations
  • PMID: 7936334
Clinical Trial

[The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]

[Article in Italian]
M R Cesarone et al. Minerva Cardioangiol. 1994 Jun.

Abstract

In 87 patients with chronic venous hypertensive microangiopathy the efficacy of oral FTTCA (Centella asiatica) administered for 60 days was tested. The microcirculatory effects of two dosages (30 mg bid and 60 mg bid) versus placebo was assessed in a double blind study. The compound was well tolerated and no unwanted effects were observed. Microcirculatory parameters--peri-malleolar skin flux at rest (RF) and transcutaneous PO2 and PCO2--improved as did the abnormally increased RF, PCO2 decreased and PO2 increased in comparison with values measured at inclusion. These results confirm the efficacy of FTTCA in venous hypertensive microangiopathy. Furthermore the effects of FTTCA appear to be dose-related.

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