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Review
. 1994 Jun;11(6):777-83.
doi: 10.1023/a:1018957103417.

Pharmaceutical applications of microcalorimetry

M J Koenigbauer  1
Affiliations
Review

Pharmaceutical applications of microcalorimetry

M J Koenigbauer. Pharm Res. 1994 Jun.

Abstract

General principles and applications of microcalorimetry are reviewed. Microcalorimetry is useful in the study of physical, chemical, and biological drug interactions. The sensitivity of the present instrumentation is approximately 0.1 microW. With this high sensitivity, additional applications have been developed, including the interactions of drugs with food, lymphoma cells, microorganisms, blood, excipients, and cyclodextrin. A recent application of microcalorimetry is the measurement of degradation rates of drugs.

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