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. 1994 Sep 27;91(20):9505-8.
doi: 10.1073/pnas.91.20.9505.

Cerebrodiene: a brain lipid isolated from sleep-deprived cats

R A Lerner  1 , G Siuzdak, O Prospero-Garcia, S J Henriksen, D L Boger, B F Cravatt
Affiliations

Cerebrodiene: a brain lipid isolated from sleep-deprived cats

R A Lerner et al. Proc Natl Acad Sci U S A. .

Abstract

We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

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References

    1. Proc Natl Acad Sci U S A. 1969 Nov;64(3):1057-64 - PubMed
    1. J Lipid Res. 1983 Oct;24(10):1389-97 - PubMed
    1. Science. 1989 Jan 27;243(4890):500-7 - PubMed
    1. Cell. 1994 May 6;77(3):329-34 - PubMed
    1. J Biol Chem. 1994 Feb 4;269(5):3125-8 - PubMed

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