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. 1976 Nov;17(11):844-8.
doi: 10.1136/gut.17.11.844.

Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis

H C Thomas, R Holden, J V Jones, D B Peacock

Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis

H C Thomas et al. Gut. 1976 Nov.

Abstract

In primary biliary cirrhosis, the primary immune response to the bacteriophage phi X 174 is normal but the secondary response is significantly reduced. The reduction is primarily of IgG antibody, while IgM is proportionately less affected. These changes may be the result of a reduction in helper T lymphocyte function and may contribute to the increase in the ratio of serum concentration of IgM to IgG.

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