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. 1994 Oct 7;266(5182):126-9.
doi: 10.1126/science.7939632.

Interaction of the protein kinase Raf-1 with 14-3-3 proteins

H Fu  1 , K Xia, D C Pallas, C Cui, K Conroy, R P Narsimhan, H Mamon, R J Collier, T M Roberts
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Interaction of the protein kinase Raf-1 with 14-3-3 proteins

H Fu et al. Science. .

Abstract

Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.

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