[The conditioned reflex behavior of dogs to the intracaudate administration of corticoliberin]

Abstract

Situational conditioned reflexes in dogs were studied before and after intracaudate bilateral microinjections of corticoliberin (CRF). Intracaudate microinjections led to an enhancement of locomotor activity, the restoration of earlier extinct exploratory behaviour, impairment of differentiation inhibition, changes of emotional reactions. Behavioural changes were accompanied by shifts of cortisol, vasopressin, norepinephrine and adrenalin levels in blood of experimental animals. The maximal impairment of conditioned behaviour was observed 30 min after CRF microinjections and coincided with maximal activation of pituitary-adrenocortical system. On the basis of the data obtained we conclude that CRF-sensitive systems of the neostriatum participate in the mechanisms, underlying behavioural, vegetative and hormonal changes.