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Clinical Trial
. 1994;35(2):155-63.
doi: 10.1186/BF03548343.

Field trials with a new genetically engineered vaccine for protection against progressive atrophic rhinitis in pigs

A Bording  1 , K Nymark, E Smidt
Affiliations
Clinical Trial

Field trials with a new genetically engineered vaccine for protection against progressive atrophic rhinitis in pigs

A Bording et al. Acta Vet Scand. 1994.

Abstract
in English, German

Field trials were carried out testing a new genetically engineered vaccine against Progressive Atrophic Rhinitis. The vaccine contained a non-toxic recombinant derivative of the P. multocida toxin. The experimental vaccine was compared with a commercial vaccine in 4 farms and in 1 farm 2 different dose regimens were applied. A total of 825 sows were included. The primary efficacy variable was a comparison of post mortem evaluation of the degree of conchae atrophy in the 4585 pigs. The pigs were slaughtered at normal slaughter weight. The secondary efficacy variables were serological response and age at slaughter. In all farms the experimental vaccine provided significantly better protection of the progeny than the control vaccine. The serological response in sows was significantly higher in all farms than the response to the control vaccine. The serological response did not differ between farms.

Der er blevet udført kliniske afprøvninger med en ny, gensplejset vaccine mod nysesyge (progressiv atrofisk rhinitis). Vaccinen indeholdt et ikke toksisk derivat af Pasteurella multocida toksinet. Derivatet var oprenset ved saltfældning før tilblanding til vaccinen. Den ekspenmentelle vaccine blev sammenlignet med en kommercielt tilgængelig toxoid vaccine mod atrofisk rhinitis i 4 besætninger. I en besætning blev den ekspenmentelle vaccine anvendt med to forskellige doseringer. I alt indgik der i undersøgelserne 826 søer og deres kuld fra 5 forskellige so- og slagtesvmebesætninger. Søerne ι begge forsøgsgrupper blev vaccineret to gange, 6-8 og 2-3 uger før faring. Vaccinernes effektivitet blev primært vurderet ved, at der efter grisenes slagtning ved normal slag-tevægt blev foretaget en sammenligning af graden af atrofi af næsehulens conchae hos 4.575 grise. Sekundært blev effekten vurderet ud fra søernes serologiske respons og grisenes alder ved slagtning. I alle besætningerne ydede den ekspenmentelle vaccine bedre beskyttelse af grisene end kontrolvaccinen. Det serologiske respons i søerne var signifikant højere i alle besætninger end responset mod kontrolvaccinen Det serologiske respons mod den ekspenmentelle vaccine var ens i de forskellige besætninger. I en besætning blev grisenes alder ved slagtning beregnet. Grise født af søer, der var vaccineret med den ekspenmentelle vaccine, nåede slagtevægten ca. 5 dage hurtigere end grise i den kontrolvaccinerede gruppe.

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References

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