[Alpha-fetoprotein synthesis during liver regeneration in adult mice of different strains]

Abstract

Alpha-fetoprotein (AFP) concentration was estimated by radial immunodiffusion in agar technique in the sera of adult mice of 12 inbred strains and F1 hybrids (SWR X B10D2 and B10D2 X SWR) during liver regeneration after CCl4 poisoning. Statistically significant difference in the AFP concentration was found in the male and female sera in 6 of 10 mouse strains studied. The following inter-strain differences were also revealed: the AFP mean levels in the sera of C57BL/6 and B10D2 strains were found to be significantly lower than the corresponding levels in the sera of the majority of the strains tested. F1 hybrids showed to occupy an intermediate position by the AFP content between the parental strains. Small, but statistically significant, differences were revealed between the groups of male F1 hybrids from the direct reciprocal crossings. It is suggested that the control of induction of the AFP synthesis during the liver regeneration in adult mice was realized on the polygene basis.