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Clinical Trial
. 1994 Jul;38(1):77-9.
doi: 10.1111/j.1365-2125.1994.tb04325.x.

The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients

R A Yeates  1 , M Ruhnke, G Pfaff, A Hartmann, M Trautmann, E Sarnow
Affiliations
Clinical Trial

The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients

R A Yeates et al. Br J Clin Pharmacol. 1994 Jul.

Abstract

The pharmacokinetics of fluconazole after a single 100 mg i.v. dose were studied in 10 healthy subjects (5 M; 5 F) and 10 HIV-positive patients (8 M; 2 F). The mean value of plasma clearance was 25% lower in the patient groups (17 +/- 6 (s.d.) vs 23 +/- 4 ml min-1; 95% CI of difference -11 to -0.7; P < 0.05). This difference may have been related to slightly reduced kidney function in the patient group (mean creatinine clearance -18%) but is unlikely to be clinically significant. Therefore, no adjustment of the dose of intravenously administered fluconazole appears to be necessary in AIDS patients without clinical signs of enteropathy.

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