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. 1994 Sep;8(9):687-91.
doi: 10.1002/rcm.1290080904.

Matrix-assisted laser desorption/ionization mass spectrometry of restriction enzyme-digested plasmid DNA using an active Nafion substrate

J Bai  1 , Y H Liu, D M Lubman, D Siemieniak
Affiliations

Matrix-assisted laser desorption/ionization mass spectrometry of restriction enzyme-digested plasmid DNA using an active Nafion substrate

J Bai et al. Rapid Commun Mass Spectrom. 1994 Sep.

Abstract

Matrix-assisted laser desorption/ionization using a 3-hydroxypicolinic acid matrix from an active Nafion substrate has been used for detection of restriction enzyme-digested double-stranded plasmid DNA using time-of-flight mass spectrometry. DNA strands of up to 267 base pairs were detected with minimal sample purification, although only as species corresponding to single-stranded DNA.

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