Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Sep;8(9):727-30.
doi: 10.1002/rcm.1290080913.

Detection of 500-nucleotide DNA by laser desorption mass spectrometry

K Tang  1 , N I Taranenko, S L Allman, L Y Cháng, C H Chen
Affiliations

Detection of 500-nucleotide DNA by laser desorption mass spectrometry

K Tang et al. Rapid Commun Mass Spectrom. 1994 Sep.

Abstract

We report the first detection of DNA segments as large as 500 nucleotides by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, using picolinic acid and 3-hydroxypicolinic acid mixtures as desorption matrices. The successful detection of 500-nucleotide DNA indicates that laser mass spectrometry is now emerging as a new biotechnology tool for DNA-related research. It should be possible to utilize fast detection of large DNA segments by laser mass spectrometry for rapid human genome sequencing.

PubMed Disclaimer

Publication types

LinkOut - more resources