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Review
. 1994 Aug;4(4):581-6.
doi: 10.1016/0959-437x(94)90076-f.

Programmed cell death in Caenorhabditis elegans

M O Hengartner  1 , H R Horvitz
Affiliations
Review

Programmed cell death in Caenorhabditis elegans

M O Hengartner et al. Curr Opin Genet Dev. 1994 Aug.

Abstract

Programmed cell death in the nematode Caenorhabditis elegans requires the activities of the genes ced-3 and ced-4 and is antagonized by the activity of the gene ced-9. Cloning of these C. elegans genes has shown that two of them encode proteins with similarity to vertebrate cell death genes and has revealed that nematodes and mammals share a common pathway for programmed cell death.

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