[Results of a field study on the therapeutic value of aprotinin in traumatic shock (author's transl)]

Abstract

In the years 1971 to 1973 the therapeutic effect of Trasylol (aprotinin isolated from bovine organs) in the treatment of the traumatic shock was investigated in a controlled field study at 31 hospitals in northern Germany. The study included 4686 patients. There could be proved a significant reduction in letality by Trasylol treatment even under the broad conditions of general field application. The therapeutic activity of Trasylol was most efficient when Trasylol was applied within 30 min after the trauma and consists especially of a better prognostic for further development. The letality after 12 h is remarkably reduced by an early application of Trasylol and posttraumatic surgical operations have a significantly lower risk.