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. 1994 Feb;14(1):59-69.
doi: 10.1007/BF02088589.

Evidence for the production and action of interleukin-10 in pituitary cells

T K Hughes  1 , P Cadet, P L Rady, S K Tyring, R Chin, E M Smith
Affiliations

Evidence for the production and action of interleukin-10 in pituitary cells

T K Hughes et al. Cell Mol Neurobiol. 1994 Feb.

Abstract

1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neuroendocrine system involving these two substances. 2. Murine pituitary tumor cells (AtT-20) were found to produce up to 3 ng/ml of IL-10. 3. Pituitary cell corticotropin production was enhanced by IL-10 treatment. 4. IL-10 induced the production of ACTH in mouse splenocytes. 5. Authenticity of pituitary-derived IL-10 was shown by the demonstration of identical nucleic acid sequences of reverse-transcribed, polymerase chain reaction amplified fragments of cDNA obtained from murine splenocytes, a murine pituitary tumor cell line, and freshly isolated murine pituitaries.

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