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. 1994 Nov;15(11):2657-9.
doi: 10.1093/carcin/15.11.2657.

N-nitroso compounds, nitrite and pH in human fasting gastric juice

B D Vu  1 , J L Paul, M Gaudric, J Guerre, J Yonger, O G Ekindjian
Affiliations

N-nitroso compounds, nitrite and pH in human fasting gastric juice

B D Vu et al. Carcinogenesis. 1994 Nov.

Abstract

Total N-nitroso compounds, ethyl acetate-extractable N-nitroso compounds and nitrite were measured in 146 samples of fasting gastric juice to investigate their relationship with pH. A positive correlation was found between pH and extractable N-nitroso compounds (r = 0.206, P < 0.02), whereas total N-nitroso compounds were pH-independent. It was inferred that pre-cancerous conditions associated with high gastric pH may be produced by an increase in the extractable N-nitroso compounds, which constitute only a small fraction of the total gastric N-nitroso compounds.

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