Transperitoneal transport of creatinine. A comparison of kinetic models

Abstract

Six kinetic models of transperitoneal creatinine transport were formulated and validated on the basis of experimental results obtained from 23 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective and lymphatic convective solute transport. The validation procedure included an assessment of theoretical (a priori) and practical (a posteriori) identifiability, goodness of fit, residual error analysis and plausibility of parameter estimates. The results of the validation procedure demonstrate that the model including all three forms of transport is superior to other models. We conclude that the best model of transperitoneal creatinine transport includes diffusion, non-lymphatic convective transport and lymphatic convective transport.