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Clinical Trial
. 1994 Sep;153(9):672-4.
doi: 10.1007/BF02190690.

Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations

R Lauterbach  1 , D Pawlik, B Tomaszczyk, B Cholewa
Affiliations
Clinical Trial

Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations

R Lauterbach et al. Eur J Pediatr. 1994 Sep.

Abstract

Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days. A statistically significant decrease in mortality rate (P < 0.04) was observed in comparison to a retrospectively analysed group of 13 septic infants, who were treated in a comparative way but without the use of a pentoxifylline infusion. The suggestion that pentoxifylline may be an effective drug in the treatment of Gram-negative sepsis in premature infants should be tested in a double-blind, randomized study.

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