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Comparative Study
. 1994 Dec;62(6):1234-7.
doi: 10.1016/s0015-0282(16)57191-x.

Human serum and follicular fluid stimulate hyperactivation of human spermatozoa after preincubation

S Kulin  1 , B A Bastiaans, H M Hollanders, H J Janssen, H J Goverde
Affiliations
Free article
Comparative Study

Human serum and follicular fluid stimulate hyperactivation of human spermatozoa after preincubation

S Kulin et al. Fertil Steril. 1994 Dec.
Free article

Abstract

Objective: To test the effects of steroid-containing media such as follicular fluid (FF) and serum and of steroid-free but human protein-rich medium on hyperactivation (HA) of human spermatozoa with and without a preincubation period.

Design: Analysis of HA using a computer-aided sperm analysis system.

Setting: Academic hospital and andrologic laboratory.

Patients: Twenty-six sperm samples were obtained from 26 different IVF patients.

Interventions: None.

Results: After a preincubation period of 3 hours, FF and serum enhanced the HA after 1 hour. A human plasma protein-rich solution did not. Without preincubation, no stimulation of HA was observed.

Conclusion: Steroids may be involved in HA, and a preincubation period may be required for an appropriate FF-induced HA.

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