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. 1978 Aug;121(2):731-5.

"Silent" alleles at the HLA-C locus

G Ferrara, R Tosi, A Longo, A Castellani, C Viviani, G Carminati
  • PMID: 79614

"Silent" alleles at the HLA-C locus

G Ferrara et al. J Immunol. 1978 Aug.

Abstract

Defined specificities of the HLA-C locus possess a significantly lower immunogenicity as compared with the HLA-A and HLA-B specificities. HLA-C "blanks" are not immunogenic at all. Among the possible explanations, the most likely one appears to be a low phenotypic expression of these alleles. C locus antigens as a whole are thus likely to be of minor relevance in donor/recipient matching for transplantation.

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