Comparative Study
doi: 10.1111/j.1600-0684.1994.tb00105.x.
Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells
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- PMID: 7966237
- DOI: 10.1111/j.1600-0684.1994.tb00105.x
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Comparative Study
Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells
J Med Primatol.
1994 Feb-May.
Abstract
Homologous SIVsm stocks were generated by passage of a macaque isolate of SIVsm (SIVsm/E660) in human CEM x 174 cells or macaque peripheral blood mononuclear cells. Macaques were immunized with whole inactivated SIV vaccine consisting of virus generated by transfection of CEM x 174 cells with the SIVsmH4 clone and were challenged with either cell-free stock. Only vaccinees challenged with virus generated in human cells were protected from infection. This confirms the species-specificity of whole inactivated vaccine-mediated protection.
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