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Comparative Study
. 1994 Feb-May;23(2-3):75-82.
doi: 10.1111/j.1600-0684.1994.tb00105.x.

Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells

S Goldstein  1 , W R Elkins, W T London, A Hahn, R Goeken, J E Martin, V M Hirsch
Affiliations
Comparative Study

Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells

S Goldstein et al. J Med Primatol. 1994 Feb-May.

Abstract

Homologous SIVsm stocks were generated by passage of a macaque isolate of SIVsm (SIVsm/E660) in human CEM x 174 cells or macaque peripheral blood mononuclear cells. Macaques were immunized with whole inactivated SIV vaccine consisting of virus generated by transfection of CEM x 174 cells with the SIVsmH4 clone and were challenged with either cell-free stock. Only vaccinees challenged with virus generated in human cells were protected from infection. This confirms the species-specificity of whole inactivated vaccine-mediated protection.

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