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Clinical Trial
. 1994 Nov 19;344(8934):1402-4.
doi: 10.1016/s0140-6736(94)90570-3.

Transplantation of porcine fetal pancreas to diabetic patients

C G Groth  1 , O Korsgren, A Tibell, J Tollemar, E Möller, J Bolinder, J Ostman, F P Reinholt, C Hellerström, A Andersson
Affiliations
Clinical Trial

Transplantation of porcine fetal pancreas to diabetic patients

C G Groth et al. Lancet. .

Abstract

Transplantation of fetal porcine islet-like cell clusters (ICC) reverses diabetes in experimental animals. We have now transplanted porcine ICC to ten insulin-dependent diabetic kidney-transplant patients. All patients received standard immunosuppression and, at ICC transplantation, antithymocyte globulin or 15-deoxyspergualin. ICC were injected intraportally or placed under the kidney capsule of the renal graft. Four patients excreted small amounts of porcine C-peptide in urine for 200-400 days. In one renal-graft biopsy specimen, morphologically intact epithelial cells stained positively for insulin and glucagon in the subcapsular space. We conclude that porcine pancreatic endocrine tissue can survive in the human body.

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