Studies on antilipolytic activity of antipyretics. Part I. Influence of sodium salicylate, acetylsalicylic acid, phenazone, aminophenazone, and acetophenidin on lipolysis in fever induced by E. coli pyrogen
- PMID: 796833
Studies on antilipolytic activity of antipyretics. Part I. Influence of sodium salicylate, acetylsalicylic acid, phenazone, aminophenazone, and acetophenidin on lipolysis in fever induced by E. coli pyrogen
Abstract
The fever induced by E. coli pyrogen (LPS) is accompanied by a rise of FFA and glycerol level. All tested antipyretics inhibited both thermogenesis of lipolysis produced by LPS. These results suggest that the antipyretic effect of antipyretic drugs is not confined to their action on heat-dissipating mechanisms, but may also be exerted by a depression of lipid metabolism.
Similar articles
-
Studies on antilipolytic activity of antipyretics. Part II. Influence of sodium salicylate, aminophenazone, and acetophenidin on lipolysis stimulated by noradrenaline and aminophylline in vitro.Pol J Pharmacol Pharm. 1976;28(5):437-42. Pol J Pharmacol Pharm. 1976. PMID: 1012973
-
[Studies on the effect of some antipyretics against endogenous pyrogen in rabbit].Eisei Shikenjo Hokoku. 1971;89:63-7. Eisei Shikenjo Hokoku. 1971. PMID: 5170096 Japanese. No abstract available.
-
Influence of drugs on immuno-allergic reactivity. I. The action of analgesics and antipyretics on the immune response.Rev Roum Physiol. 1973;10(3):213-20. Rev Roum Physiol. 1973. PMID: 4718587 No abstract available.
-
The pathogenesis of fever: neurochemical aspects.Isr J Med Sci. 1976 Sep;12(9):960-73. Isr J Med Sci. 1976. PMID: 187561 Review. No abstract available.
-
The pharmacology of fever.Prog Neurobiol. 1985;25(4):327-73. doi: 10.1016/0301-0082(85)90019-x. Prog Neurobiol. 1985. PMID: 3911273 Review.