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. 1994 Nov 10;372(6502):150-7.
doi: 10.1038/372150a0.

Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

K Bezouska  1 , C T Yuen, J O'Brien, R A Childs, W Chai, A M Lawson, K Drbal, A Fiserová, M Pospísil, T Feizi
Affiliations

Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

K Bezouska et al. Nature. .

Erratum in

  • Nature 1996 Apr 11;380(6574):559

Retraction in

Abstract

A diversity of high-affinity oligosaccharide ligands are identified for NKR-P1, a membrane protein on natural killer (NK) cells which contains an extracellular Ca(2+)-dependent lectin domain. Interactions of such oligosaccharides on the target cell surface with NKR-P1 on the killer cell surface are crucial both for target cell recognition and for delivery of stimulatory or inhibitory signals linked to the NK cytolytic machinery. NK-resistant tumour cells are rendered susceptible by preincubation with liposomes expressing NKR-P1 ligands, suggesting that purging of tumour or virally infected cells in vivo may be a therapeutic possibility.

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