[Theory of generator mechanisms in several neuropathologic syndrome]

Abstract

This report formulates a general concept of the role played by determinant structures in CNS functioning and a related theory of generator mechanism which underlines neuropathological syndromes characterized by hyperactivity of cerebral centers. The theory postulates that due to deficiency of inhibitory mechanisms some populations of neurones become generators of abnormally enhanced excitation. Such generators operate as hyperactive determinant structures (or hyperactive determinant dispatch stations, DDS) inducing pathological changes in various functional systems and determining their behaviour. Formation of hyperactive DDS generating excitation in certain parts of the CNS leads to the appearance of corresponding neuropathological syndromes. This theory was used as a basis for experiments which reproduced pain syndromes of a central origin (including the trigeminal syndrome, the thalamic syndrome and phantom pains) vestibulopathy, photogenous epilepsy, catalepsy, manifestations of parkinsonism, etc. The report describes the characteristics of the generators of abnormally enhanced excitation. Some features of their operation are correlated with the course of the syndromes. Certain problems of pathogenetically oriented therapy are also discussed.